MovDisordV3, Main, Exploration, bibRecord, 002A44

[123I]FP-CIT SPET Imaging in Drug-Induced Parkinsonism

Identifieur interne : 002A44 ( Main/Exploration ); précédent : 002A43; suivant : 002A45

[123I]FP-CIT SPET Imaging in Drug-Induced Parkinsonism

Auteurs : Michele Tinazzi [Italie] ; Sarah Ottaviani [Italie] ; Ioannis U. Isaias [Italie] ; Isabella Pasquin [Italie] ; Maria Steinmayr [Italie] ; Claudio Vampini [Italie] ; Manuela Pilleri [Italie] ; Giuseppe Moretto [Italie] ; Antonio Fiaschi [Italie] ; Nicola Smania [Italie] ; Piergiorgio Giorgetti [Italie] ; Angelo Antonini [Italie]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0522182

Descripteurs français

Pascal (Inist)
- Parkinsonisme, Maladie de Parkinson, Pathologie du système nerveux, Tomoscintigraphie, Dopamine.

English descriptors

KwdEn :
- Dopamine, Emission tomography, Nervous system diseases, Parkinson disease, Parkinsonism.

Abstract

: We assessed the status of dopamine nerve terminals in patients treated with dopamine receptor blocking agents (DRBAs) who had developed drug-induced parkinsonism (DIP). We performed [¹²³I]FP-CIT SPET in 32 consecutive patients who were on DRBAs for at least 6 months and developed extrapyramidal signs. The UPDRS-III was used to assess clinical severity. Twenty-six age- and sex-matched healthy subjects served as control group. Putamen [¹²³I]FPCIT SPET binding was reduced in 14 and normal in the remaining 18 patients. There was no difference between the two groups for age, duration of DRBAs treatment, UPDRS III, tremor, rigidity, and bradykinesia subscores for upper and lower limbs. Conversely, symmetry of parkinsonian signs and presence bucco-linguo-masticatory dyskinesias were more frequent in individuals with normal tracer binding. Imaging of the dopamine transporter may help to identify subjects with DIP secondary to a loss of dopamine nerve terminals.

Affiliations:

Italie

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001092
to stream PascalFrancis, to step Curation: 001C27
to stream PascalFrancis, to step Checkpoint: 001018
to stream Main, to step Merge: 003626
to stream Main, to step Curation: 002A44

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">[<sup>123</sup>
I]FP-CIT SPET Imaging in Drug-Induced Parkinsonism</title>
<author><name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name>
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<author><name sortKey="Moretto, Giuseppe" sort="Moretto, Giuseppe" uniqKey="Moretto G" first="Giuseppe" last="Moretto">Giuseppe Moretto</name>
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<author><name sortKey="Fiaschi, Antonio" sort="Fiaschi, Antonio" uniqKey="Fiaschi A" first="Antonio" last="Fiaschi">Antonio Fiaschi</name>
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<author><name sortKey="Smania, Nicola" sort="Smania, Nicola" uniqKey="Smania N" first="Nicola" last="Smania">Nicola Smania</name>
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<author><name sortKey="Giorgetti, Piergiorgio" sort="Giorgetti, Piergiorgio" uniqKey="Giorgetti P" first="Piergiorgio" last="Giorgetti">Piergiorgio Giorgetti</name>
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<s2>Verona</s2>
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<wicri:noRegion>Unità Operativa di Medicina Nucleare OC Borgo Trento</wicri:noRegion>
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</author>
<author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name>
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<s3>ITA</s3>
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<sZ>12 aut.</sZ>
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<wicri:noRegion>Milano</wicri:noRegion>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dopamine</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Parkinsonisme</term>
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<front><div type="abstract" xml:lang="en">: We assessed the status of dopamine nerve terminals in patients treated with dopamine receptor blocking agents (DRBAs) who had developed drug-induced parkinsonism (DIP). We performed [<sup>123</sup>
I]FP-CIT SPET in 32 consecutive patients who were on DRBAs for at least 6 months and developed extrapyramidal signs. The UPDRS-III was used to assess clinical severity. Twenty-six age- and sex-matched healthy subjects served as control group. Putamen [<sup>123</sup>
I]FPCIT SPET binding was reduced in 14 and normal in the remaining 18 patients. There was no difference between the two groups for age, duration of DRBAs treatment, UPDRS III, tremor, rigidity, and bradykinesia subscores for upper and lower limbs. Conversely, symmetry of parkinsonian signs and presence bucco-linguo-masticatory dyskinesias were more frequent in individuals with normal tracer binding. Imaging of the dopamine transporter may help to identify subjects with DIP secondary to a loss of dopamine nerve terminals.</div>
</front>
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<affiliations><list><country><li>Italie</li>
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<tree><country name="Italie"><noRegion><name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name>
</noRegion>
<name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name>
<name sortKey="Fiaschi, Antonio" sort="Fiaschi, Antonio" uniqKey="Fiaschi A" first="Antonio" last="Fiaschi">Antonio Fiaschi</name>
<name sortKey="Giorgetti, Piergiorgio" sort="Giorgetti, Piergiorgio" uniqKey="Giorgetti P" first="Piergiorgio" last="Giorgetti">Piergiorgio Giorgetti</name>
<name sortKey="Isaias, Ioannis U" sort="Isaias, Ioannis U" uniqKey="Isaias I" first="Ioannis U." last="Isaias">Ioannis U. Isaias</name>
<name sortKey="Moretto, Giuseppe" sort="Moretto, Giuseppe" uniqKey="Moretto G" first="Giuseppe" last="Moretto">Giuseppe Moretto</name>
<name sortKey="Ottaviani, Sarah" sort="Ottaviani, Sarah" uniqKey="Ottaviani S" first="Sarah" last="Ottaviani">Sarah Ottaviani</name>
<name sortKey="Pasquin, Isabella" sort="Pasquin, Isabella" uniqKey="Pasquin I" first="Isabella" last="Pasquin">Isabella Pasquin</name>
<name sortKey="Pilleri, Manuela" sort="Pilleri, Manuela" uniqKey="Pilleri M" first="Manuela" last="Pilleri">Manuela Pilleri</name>
<name sortKey="Smania, Nicola" sort="Smania, Nicola" uniqKey="Smania N" first="Nicola" last="Smania">Nicola Smania</name>
<name sortKey="Steinmayr, Maria" sort="Steinmayr, Maria" uniqKey="Steinmayr M" first="Maria" last="Steinmayr">Maria Steinmayr</name>
<name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name>
<name sortKey="Vampini, Claudio" sort="Vampini, Claudio" uniqKey="Vampini C" first="Claudio" last="Vampini">Claudio Vampini</name>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

[123I]FP-CIT SPET Imaging in Drug-Induced Parkinsonism

[123I]FP-CIT SPET Imaging in Drug-Induced Parkinsonism

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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